Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Impact of CVVH on monocyte activation in the critically ill

Full text

Introduction

Monocyte activation (HLA-DR+ CD14+) was suggested to be a useful marker of immune system function. As extracorporeal circuit might influence the immune response (e.g. bioincompatibility and/or elimination of pro/anti-inflammatory cytokines) we investigated the impact of CVVH initiation on monocyte activation in critically ill patients.

Methods

Fifteen septic (4 ICU survivors) and 7 nonseptic (1 ICU survivor) critically ill patients in whom CVVH (ultra-filtration 1–2 l h-1) was initiated because of acute renal failure as a part of MODS. Expression of HLA-DR+ CD14+ was assessed by flow-cytometry before CVVH initiation and at 4 h and 24 h afterwards. The Friedmann two-way ANOVA and Mann-Whitney U tests were used when appropriate. Data are presented as means ± SD; P<0.05 was considered significant.

Results

Baseline HLA-DR+CD14+ values in septic and non-septic patients were not different (57± 21% and 71± 21% respectively, P=0.23). Time course of HLA-DR+CD14+ during the first 24h of CVVH are shown in Fig. 1.

Conclusion

CVVH initiation has no impact on monocyte HLA-DR expression in both septic and nonseptic patients.

figure1

Figure 1

Acknowledgement

Supported by a Grant of IGA MZ (4972-3).

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Rokyta, R., Holub, M., Matejovic, M. et al. Impact of CVVH on monocyte activation in the critically ill. Crit Care 4, P37 (2000). https://doi.org/10.1186/cc757

Download citation

Keywords

  • Public Health
  • Immune Response
  • Immune System
  • Renal Failure
  • Emergency Medicine