- Poster presentation
- Published:
Postconditioning effects following sevoflurane inhalational sedation in the ICU: a pilot study in cardiac surgery patients
Critical Care volume 13, Article number: P395 (2009)
Methods
Fifty patients either received sevoflurane via ACD or propofol for ICU sedation. The primary endpoint was a change in troponine T (TNT), besides measures of myocardial creatine kinase (CK-MB), N-terminal pro brain natriuretic peptide (NT-proBNP) and haemodynamics. Measure points were set at baseline, end of surgery, 24 hours and 48 hours after surgery.
Results
TNT and CK-MB levels were significantly higher (P < 0.0001) at all measure points compared with baseline in each group, without any significant differences between both groups. NT-proBNP values were significantly lower following sevoflurane at 24 and 48 hours (P < 0.05) compared with propofol (Figure 1).
Conclusion
Postoperative sevoflurane sedation via ACD led to lower NT-proBNP levels at 24 and 48 hours, while TNT and CK-MB values were comparable in both study groups.
References
Röhm KD, et al: Short-term sevoflurane sedation using the Anaesthetic Conserving Device after cardiothoracic surgery. Intensive Care Med. 2008, 34: 1673-1679. 10.1007/s00134-008-1157-x.
Sackey PV, et al: Prolonged isoflurane sedation of intensive care unit patients with the Anesthetic Conserving Device. Crit Care Med. 2004, 32: 2241-2246.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Röhm, K., Mayer, J., Boldt, J. et al. Postconditioning effects following sevoflurane inhalational sedation in the ICU: a pilot study in cardiac surgery patients. Crit Care 13 (Suppl 1), P395 (2009). https://doi.org/10.1186/cc7559
Published:
DOI: https://doi.org/10.1186/cc7559