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Postconditioning effects following sevoflurane inhalational sedation in the ICU: a pilot study in cardiac surgery patients
Critical Care volume 13, Article number: P395 (2009)
Fifty patients either received sevoflurane via ACD or propofol for ICU sedation. The primary endpoint was a change in troponine T (TNT), besides measures of myocardial creatine kinase (CK-MB), N-terminal pro brain natriuretic peptide (NT-proBNP) and haemodynamics. Measure points were set at baseline, end of surgery, 24 hours and 48 hours after surgery.
TNT and CK-MB levels were significantly higher (P < 0.0001) at all measure points compared with baseline in each group, without any significant differences between both groups. NT-proBNP values were significantly lower following sevoflurane at 24 and 48 hours (P < 0.05) compared with propofol (Figure 1).
Postoperative sevoflurane sedation via ACD led to lower NT-proBNP levels at 24 and 48 hours, while TNT and CK-MB values were comparable in both study groups.
Röhm KD, et al: Short-term sevoflurane sedation using the Anaesthetic Conserving Device after cardiothoracic surgery. Intensive Care Med. 2008, 34: 1673-1679. 10.1007/s00134-008-1157-x.
Sackey PV, et al: Prolonged isoflurane sedation of intensive care unit patients with the Anesthetic Conserving Device. Crit Care Med. 2004, 32: 2241-2246.
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Röhm, K., Mayer, J., Boldt, J. et al. Postconditioning effects following sevoflurane inhalational sedation in the ICU: a pilot study in cardiac surgery patients. Crit Care 13, P395 (2009). https://doi.org/10.1186/cc7559
- Creatine Kinase
- Brain Natriuretic Peptide
- Volatile Anaesthetic
- Cardiac Surgery Patient