Volume 13 Supplement 1

29th International Symposium on Intensive Care and Emergency Medicine

Open Access

Procalcitonin: a prognostic marker for critically ill

  • M Bhattacharyya1 and
  • S Todi1
Critical Care200913(Suppl 1):P388

https://doi.org/10.1186/cc7552

Published: 13 March 2009

Introduction

Procalcitonin (PCT) is a marker of sepsis and the levels correlate with the severity of illness.

Methods

A prospective, observational study conducted in the medical surgical intensive therapy unit of a tertiary-care centre in India. Three hundred critically ill adult patients with suspected sepsis during any time of the intensive therapy unit stay in whom PCT was estimated were included in the study. PCT was assessed by quantitative immunoluminometric assay. The demographics of the study population, and APACHE II and APACHE IV scores were recorded.

Results

Demographic character of the study population was as follows: median age 61 years, male:female ratio 174:126, median APACHE II and APACHE IV scores 17 and 59, respectively, and medical:surgical patients 265:35. See Table 1 and Figure 1 for receiver operating characteristic analysis.
Table 1

Comparison between APACHE II, APACHE IV and PCT

 

APACHE II

APACHE IV

PCT

Area under the curve

0.66

0.693

0.63

Cutoff value

17

57.5

0.93

Sensitivity

64

71.6

73.6

Specificity

62.4

57.4

57.6

Positive predictive value

41.95

41.41

41.84

Negative predictive value

80.33

82.78

84.04

Figure 1

Receiver operating characteristic analysis of APACHE II, APACHE IV and PCT.

Conclusion

PCT is a reliable marker for prognostication with a high negative predictive value and comparable with APACHE prediction models.

Authors’ Affiliations

(1)
AMRI Hospitals Kolkata

Copyright

© Bhattacharyya and Todi; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.

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