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Serum high-mobility group box-1 protein as a specific marker of severe abdominal injury
Critical Care volume 13, Article number: P375 (2009)
Trauma cases who have altered consciousness are candidates for missed injury of the abdomen. A specific marker of severe abdominal trauma would therefore be considered useful for rapid evaluation and treatment of abdominal injuries in trauma cases. On the other hand, high-mobility group box-1 protein (HMGB1) has been widely studied in relation to its role in sepsis and inflammation [1, 2].
We measured the serum HMGB1 concentrations in 50 consecutive trauma patients as early as possible after they arrived in the emergency room. All cases with an abbreviated injury scale over 3 were enrolled in the study. The correlations between the serum HMGB1 levels and the body region of injury were examined. Then, a comparative evaluation of the injury severity score, revised trauma score and probability of survival was conducted in the patients with and without elevated serum HMGB1 concentrations. In addition, we measured the serum HMGB1 levels in 45 septic shock patients and the relationship between the HMGB1 level and underlying disease.
There were no significant correlations between the serum HMGB-1 levels and the presence of severe head, chest or extremity injury. On the other hand, the serum HMGB1 levels were significantly higher in the subject group with severe abdominal injury (mean HMGB-1 level, 16.9 ng/ml; 10 cases) as compared with that in the subject group without severe abdominal injury (mean HMGB-1 level, 2.2 ng/ml; 40 cases) (P = 0.0069). In septic shock patients, the serum HMGB1 levels were significantly higher in the subject group with peritonitis (mean HMGB-1 level, 19.1 ng/ml; 22 cases) as compared with that in the subject group without peritonitis (mean HMGB-1 level, 8.8 ng/ml; 23 cases) (P = 0.0447).
According to our data, high serum levels of HMGB1 were not correlated with an increased likelihood of head injury, chest injury or extremity injury, but were significantly correlated with the presence of severe abdominal injury. This result suggests the possibility of the serum HMGB-1 level representing a specific marker of severe abdominal injury.
Sakamoto Y, et al.: Relationship between effect of polymyxin B-immobilized fiber and high mobility group box-1 protein in septic shock patients. ASAIO J 2007, 53: 324-328. 10.1097/MAT.0b013e3180340301
Sakamoto Y, et al.: Clinical responses and improvement of some laboratory parameters following polymyxin B-immobilized fiber treatment in septic shock. ASAIO J 2007, 53: 646-650. 10.1097/MAT.0b013e3181492395
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Sakamoto, Y., Mashiko, K., Matsumoto, H. et al. Serum high-mobility group box-1 protein as a specific marker of severe abdominal injury. Crit Care 13, P375 (2009). https://doi.org/10.1186/cc7539
- Injury Severity Score
- Subject Group
- Abdominal Trauma
- Septic Shock Patient