- Poster presentation
- Open Access
Compliment activity patterns in patients with sepsis after human purified C1-esterase inhibitor infusion
© Igonin et al; licensee BioMed Central Ltd. 2009
- Published: 13 March 2009
- Complement Activity
- Sepsis Patient
- Baseline Result
- Baseline Activity
Our purpose was to assess the effects of super physiologic dosages of human purified C1-esterase inhibitor infusion (C1INH) on complement-dependent pathways of systemic inflammatory response in patients with sepsis.
In the terms of an open-label prospective control study, human purified C1INH (Bicizar; BioGenius LLC, Russia) was administered at total dosage of 12,000 U to 20 sepsis patients. Patients (n = 22) who did not receive C1INH infusion were enrolled as controls. C3 and C4 complement subunits, IL-6, C-reactive protein and procalcitonin results were analyzed in quartiles according to C1INH baseline activity.
Downregulation of complement activity with C1INH might help to contain severe systemic inflammation. Presumably, the response to C1INH infusion was related to its baseline activity.
This article is published under license to BioMed Central Ltd.