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Adaptability of muscle tissue oxygenation to repeated vascular occlusion


Dynamic testing of muscle tissue oxygenation (StO2) with near-infrared spectroscopy and vascular occlusion (VOT) is a developing area of research in critical care. VOT is often performed multiple times during analysis. We report the impact of repeated VOT on StO2 parameters.


Twenty-five healthy subjects were studied with the InSpectra 650 monitor and a 15 mm probe. VOT was set at systolic blood pressure + 50 mmHg for 3 minutes in triplicate. Each VOT was separated by a 5-minute rest period. StO2 data are reported for baseline%, downslope (DS) and upslope (US)%/min, overshoot%, area over the ischaemic curve (AOC Isch) and area under the recovery curve (AUC Rec)%/min and recovery time (Rec Time) in minutes. Data were compared by ANOVA.


See Table 1.

Table 1 Population StO2 means (± SD) for consecutive VOT and significance


It is important to understand the impact of serial VOT. We have observed sequential change in rates of StO2 decline during ischaemia (reduced DS gradients, total drop and AOC Isch). Although the overshoot was unchanged, the AUC Rec and Rec time demonstrated increases approaching significance. These patterns imply a preconditioned adaptation to repeated VOT and an exaggerated hyperaemic response. Further studies are required to determine acceptable rest periods between VOTs to ameliorate these changes.

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Thomson, S., Al-Subaie, N., Hamilton, M. et al. Adaptability of muscle tissue oxygenation to repeated vascular occlusion. Crit Care 13 (Suppl 1), P241 (2009).

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  • Systolic Blood Pressure
  • Critical Care
  • Recovery Time
  • Rest Period
  • Dynamic Testing