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Relation between mixed venous and central venous saturation in sepsis: influence of source of sepsis
Critical Care volume 13, Article number: P227 (2009)
There remains controversy concerning the use of central venous oxygen saturation (ScvO2) or mixed venous oxygen saturation (SvO2) as a marker for resuscitation, including their interchangeability [1, 2]. We tested the hypothesis that in sepsis ScvO2 does not reliably predict SvO2, independent of the sepsis origin.
We determined ScvO2 and SvO2 in a group of patients with sepsis in 6-hour intervals during the first 24 hours after acute admission.
Data of 29 septic patients were collected: 10 patients with abdominal sepsis and 19 patients with other sources of sepsis (nonabdominal group) (Table 1). Univariate analysis from the total population and both groups separately did not show any parameter (cardiac output, cardiac index, dopamine, nor-epinephrine, arterial saturation, hemoglobin, hematocrit and lactate) affecting Δ(ScvO2 - SvO2). See Figure 1.
We conclude that in sepsis ScvO2 does not reliably predict SvO2, independent of the sepsis origin. The difference between ScvO2 and SvO2 in sepsis appears not to be a fixed one. Also, this difference seems independent of several hemodynamic parameters.
Dueck MH, Klimek M, Appenrodt S, Weigand C, Boerner U: Trends but not individual values of central venous oxygen saturation agree with mixed venous oxygen saturation during varying hemodynamic conditions. Anesthesiology 2005, 103: 249-257. 10.1097/00000542-200508000-00007
Varpula M, Karlsson S, Ruokonen E, Pettilä V: Mixed venous oxygen saturation cannot be estimated by central venous oxygen saturation in septic shock. Intensive Care Med 2006, 32: 1336-1343. 10.1007/s00134-006-0270-y
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Van Beest, P., Koopmans, M., Ingen, J.V. et al. Relation between mixed venous and central venous saturation in sepsis: influence of source of sepsis. Crit Care 13, P227 (2009). https://doi.org/10.1186/cc7391
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