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Calibration of pulse contour continuous cardiac output analysis


We evaluated the effect of the calibration interval on the reliability of pulse contour cardiac output (COpc) measurement [1].


Eleven patients were investigated for over 10 hours using two COpc monitors simultaneously. One COpc (COpcCAL) monitor was calibrated hourly, while the other (COpcNOCAL) was calibrated once initially without any further calibration. COpcCAL was compared with COpcNOCAL.


A total of 116 pairs of cardiac output measurement was obtained. After 3 hours, the correlation between COpcCAL and COpcNOCAL was r2 = 0.85, P < 0.0001, bias ± SD was -0.43 ± 0.87 ml/minute; after 6 hours, r2 = 0.68, P = 0.0064, bias ± SD was -0.83 ± 1.39 ml/minute; after 10 hours, r2 = 0.70, P = 0.0026, bias ± SD was -0.81 ± 1.21 ml/minute. See Figures 1 and 2.

Figure 1
figure 1

Line regression between COpcCAL and COpcNOCAL.

Figure 2
figure 2

Bland–Altman plot of COpcCAL and COpcNOCAL. Solid line, bias; dashed lines, ± 2 SD.


The calibration interval has no effect on the reliability of the COpc measurement.


  1. Gödje O, et al.: Reliability of a new algorithm for continuous cardiac output determination by pulse-contour analysis during hemodynamic instability. Crit Care Med 2002, 30: 52-58. 10.1097/00003246-200201000-00008

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Weng, L., Du, B., Hu, X. et al. Calibration of pulse contour continuous cardiac output analysis. Crit Care 13 (Suppl 1), P206 (2009).

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  • Public Health
  • Cardiac Output
  • Emergency Medicine
  • Output Measurement
  • Output Analysis