Volume 13 Supplement 1
Which variables affect strict glycaemic control with intensive insulin therapy in postoperative/post-traumatic critically ill patients?
© Weiss et al; licensee BioMed Central Ltd. 2009
Published: 13 March 2009
This study was performed to determine the effect variables supposed to affect optimal blood glucose concentrations between 80 and 150 mg/dl in postoperative/post-traumatic patients.
From January 2007 to December 2007, 826 postoperative/post-traumatic critically ill patients admitted to a university adult ICU performing intensive insulin therapy were surveyed daily using computer assistance with respect to minimal and maximal daily blood glucose concentrations and insulin therapy. The variables age, sex, sepsis, neurosurgical patient, steroids, adrenaline and/or noradrenaline infusion rate, acute renal failure, liver function assessed by the Model of Endstage Liver Disease score , organ dysfunctions reflected by the Sequential Organ Failure Assessment score , and severity of disease by the Simplified Acute Physiology Score II  were monitored.
Seven hundred and sixty-four patients with an ICU stay >48 hours were eligible for evaluation. In multiple logistic regression with backward elimination to determine the most relevant parameters, sepsis (OR = 1.2, with corresponding 95% CI = 1.1 to 1.4), neurosurgical patients (OR = 1.6, CI = 1.3 to 1.9), steroids (OR = 1.5, CI = 1.2 to 1.9), noradrenaline infusion (OR = 1.4, 95% CI = 1.2 to 1.6), and age (per year) (OR = 1.02, CI = 1.01 to 1.02) were associated with an increased risk not to lay within an optimal blood glucose range of 80 to 150 mg/dl (P < 0.01).
Sepsis, neurosurgery, steroids, catecholamine infusions and age may be associated with increased risk for difficult blood glucose control in postoperative/post-traumatic patients.
- Kamath PS, Wiesner RH, Malinchoc M, et al.: A model to predict survival in patients with end-stage liver disease. Hepatology 2001, 33: 464-470. 10.1053/jhep.2001.22172PubMedView ArticleGoogle Scholar
- Vincent JL, de Mendonca A, Cantraine F, et al.: Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on 'sepsis-related problems' of the European Society of Intensive Care Medicine. Crit Care Med 1998, 26: 1793-1800.PubMedView ArticleGoogle Scholar
- Le-Gall JR, Lemeshow S, Saulnier F: A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 1993, 270: 2957-2963. 10.1001/jama.270.24.2957PubMedView ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd.