- Poster presentation
High fluid volume removal with continuous renal replacement therapy as a therapeutic option for early posttraumatic acute respiratory distress syndrome
Critical Care volume 12, Article number: P477 (2008)
The increase in vascular permeability, due to capillary leakage, seems to be responsible for high density on CT lung examination and worsening of gas exchange in acute respiratory distress syndrome (ARDS) patients. An improvement of the PaO2/FiO2 ratio and ARDS reversal following lung water removal has been shown. The aim of our study was to investigate whether hourly depletion of high fluid volume through continuous renal replacement therapy (CRRT) could reverse posttraumatic ARDS. The body water redistribution in different compartments can lead to a rapid decrease in extravascular lung water (EVLW).
Three trauma patients, fulfilling ARDS criteria within 48 hours since traumatic nonbrain injury (early posttraumatic ARDS), underwent protective lung ventilation with moderate to high positive end-expiratory pressure, maintaining end-tidal CO2 < 60 mmHg. All patients developed acute renal failure. The patients were treated with CRRT with 45 ml/kg/hour ultrafiltration and 500 ml/hour fluid volume removal. Modified Swan–Ganz and arterial catheters (Picco) were inserted for cardiovascular and EVLW index (EVLWI) monitoring.
The haemodynamic variables, the gas exchange values and the fluid balance are reported in Figures 1 and 2. Rapid high fluid volume depletion decreased the EVLWI, providing a complete resolution of ARDS and leading to extubation of all three patients within 72 hours from the beginning of CRRT. The treatment was uneventful and all the patients showed haemodynamic stability.
This approach seems to be a possible treatment option for early posttraumatic ARDS. In our opinion this study could introduce a new therapeutic choice that might decrease days of mechanical ventilation.
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Gattinoni L, et al: N Engl J Med. 2006, 354: 1775-1786. 10.1056/NEJMoa052052.
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Sorrentino, L., De Sanctis, F., Mercieri, M. et al. High fluid volume removal with continuous renal replacement therapy as a therapeutic option for early posttraumatic acute respiratory distress syndrome. Crit Care 12, P477 (2008). https://doi.org/10.1186/cc6698
- Acute Respiratory Distress Syndrome
- Continuous Renal Replacement Therapy
- Lung Ventilation
- Volume Depletion
- Capillary Leakage