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Sedation during mechanical ventilation: a comparison of sedatonarcosis and awake sedation
© BioMed Central Ltd 2008
Published: 13 March 2008
The most important goal during mechanical ventilation in the ICU is to achieve patient comfort and patient–ventilator synchrony. Once proper analgesia has been established, an infusion of a sedative should be added. The goal of this study was to investigate whether continuously awake sedation during mechanical ventilation (MV) decreased the days of ventilation and complications.
All patients with MV – based on the abovementioned criteria – were included (age: 20–70 years; community-acquired pneumonia; two quadrant infiltrates; PaO2/FiO2 < 200; no other organ dysfunction). From June 2001 to February 2004, patients with MV received deep sedation (midazolam 0.03–0.20 mg/kg body weight/hour and propofol 0.5–2.0 mg/kg body weight/hour). This is the 'sedatonarcosis' group. From March 2004 to July 2007, patients were treated with 'awake sedation' (alprasolam 1.5–2.0 mg/day).
MV (average, days)
Length of ICU stay (average, days)
Length of hospital stay (average, days)
Sedatonarcosis group (n = 21)
Awake sedation group (n = 23)
Adopting awake sedation during MV (compared with continuous sedatonarcosis) decreased the days on ventilation, and the lengths of ICU and hospital stay.
This article is published under license to BioMed Central Ltd.