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Is the ratio of lactated to pyrostaphylic acid in cerebral tissue a prognostic index for the outcome of patients with intracerebral hemorrhage?
© BioMed Central Ltd 2008
Published: 13 March 2008
The objective was to correlate the ratio of lactated to pyrostaphylic acid (L/P) with the outcome of patients with intracerebral hemorrhage, according to the Glasgow Outcome Scale (GOS).
ICU patients with spontaneous intracerebral hemorrhage, diagnosed with a brain CT, were enrolled in the study. The inclusion criterion was a GCS on admission <8. An intracranial microdialysis catheter was inserted in cerebral tissue and extracellular brain fluid sample was collected every 2 hours for analysis. A CMA 600 Microdialysis Analyzer was used for measurements. Patients were divided into two groups according to their GOS score 6 months later, group A (GOS 4–5, good outcome) and group B (GOS 1–3, poor outcome). The variable of L/P was dichotomized and a value that was statistically significant correlated to the outcome was investigated. Comparison of the mean value of L/P between the two groups was carried out at a significance level of 95%.
Correlation between L/P ratio and GOS scale
GOS 4–5 (n = 6)
GOS 1–3 (n = 23)
L/P < 37
L/P ≥ 37
Fisher's exact test
P = 0.028
According to our results, the lactated to pyrostaphylic acid ratio is correlated to the outcome of patients with intracerebral hemorrhage, 6 months after admission to the ICU.
This article is published under license to BioMed Central Ltd.