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  • Poster presentation
  • Open Access

Diastolic function abnormalities in ICU patients with chronic obstructive pulmonary disease

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Critical Care200812 (Suppl 2) :P83

  • Published:


  • Chronic Obstructive Pulmonary Disease
  • Chronic Obstructive Pulmonary Disease Patient
  • Leave Ventricular Function
  • Diastolic Leave Ventricular Function
  • Diastolic Diameter


It has been shown from several studies that patients with right ventricle pressure overload often have left ventricular (LV) diastolic dysfunction. Our aim was to evaluate LV function in ICU patients with chronic obstructive pulmonary disease (COPD).


We studied 35 patients (20 males, 15 females), mean age 65 ± 8.4 years, with COPD and without comorbidities (hypertension, diabetes, coronary heart disease or heart failure). Twenty-five healthy subjects matched for age and sex were used for control. Using conventional echocardiography, the LV end diastolic diameter (LVD), LV ejection fraction (EF%), right ventricle diastolic diameter (RVD), right ventricle systolic pressure (RVSP), the maximal velocity of E wave, maximal velocity of A wave, and E/A ratio were assessed. Using tissue Doppler echocardiography, Em, Am and Em/Am were calculated.


The differences between groups are presented in Figure 1. The parameters of the diastolic LV function, E/A and Em/Am were significantly lower in COPD patients in comparison with healthy subjects. There was also a significant negative correlation between RVSP and Em/Am (r = -0.74, P < 0.01) and E/A (r = 0.5; P < 0.005).

Figure 1


Systolic LV function is well preserved in COPD patients but we found a severe LV diastolic impairment that might be due to alterations of the chamber stiffness from the hypertrophic right ventricle.

Authors’ Affiliations

Metaxa Hospital, Athens, Greece


© BioMed Central Ltd 2008

This article is published under license to BioMed Central Ltd.