Volume 12 Supplement 2

28th International Symposium on Intensive Care and Emergency Medicine

Open Access

Relationship between the sublingual microcirculation and lactate levels in patients with heart failure

  • CA Den Uil1,
  • WK Lagrand2,
  • E Klijn1,
  • C Ince1,
  • PE Spronk3 and
  • ML Simoons1
Critical Care200812(Suppl 2):P62

https://doi.org/10.1186/cc6283

Published: 13 March 2008

Introduction

Treatment of patients with severe heart failure aims at normalizing hemodynamic and metabolic parameters. We tested whether the sublingual functional capillary density (FCD), an indicator of tissue perfusion at the microvascular level, correlates with lactate levels in heart failure patients.

Methods

We investigated 12 heart failure patients, treated with inotropes, within 24 hours after hospital admission. Sidestream dark-field imaging was used to investigate the sublingual microcirculation. At least three video sequences of the microcirculation were recorded and analyzed. Microscan Analysis Software was used to measure the FCD, where the FCD was determined as the total length of perfused capillaries per field of view. Capillaries were defined as microvessels with a diameter <25 μm.

Results

The mean arterial pressure was 75 (68–78) mmHg, lactate levels were 1.2 (1.0–1.7) mmol/l and SvO2 was 0.78 (0.65–0.84) mol/mol. The FCD was 11.7 (10.1–12.2) μm-1. The correlation between lactate and FCD is shown in Figure 1 (regression line: β1 = -0.88, P = 0.05).

Figure 1

Conclusion

In this study, FCD correlated with lactate levels. This finding is indicative for a relationship between global hemodynamics and the sublingual microcirculation in patients treated for heart failure. Based on the interim results, more patients will be included in this study for final analysis and conclusions.

Authors’ Affiliations

(1)
Erasmus Medical Center
(2)
Leiden University Medical Center
(3)
Gelre Hospitals

Copyright

© BioMed Central Ltd 2008

This article is published under license to BioMed Central Ltd.

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