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Serum S100 as a marker of cerebral injury in acute liver failure (ALF) and during orthotopic liver transplantation (OLT)

Introduction

Encephalopathy and irreversible cerebral injury may occur in ALF. S100 is a CNS-specific protein that is a marker of cerebral injury [1,2]. We investigated S100 protein in patients with ALF who underwent OLT.

Methods

After IRB approval blood samples were taken in 10 patients age 20-51 years with ALF. Blood was taken before OLT (A), during the anhepatic phase (B), 30 min after reperfusion (C), and on days 1 (D) and 4 (E) post-OLT. The blood was centrifuged and serum stored at -70°C. S100 was analysed using an immunoluminometric assay.

Results

Serum S100 (X ± SEM) was elevated prior to OLT (normal < 0.12 µg/l). By day 4 post-OLT S100 had fallen in all patients except one. This patient subsequently died.

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Conclusion

Serum S100 is elevated in ALF and encephalopathy. We observed a rise in S100 during OLT in these patients. The role of S100 as a marker of neuronal injury in ALF and OLT warrants further investigation.

References

  1. 1.

    Stroke 1997, 28: 1956.

  2. 2.

    Ann Clin Biochem 1997, 34: 546-550.

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Leonard, S., Watts, A., Parmar, K. et al. Serum S100 as a marker of cerebral injury in acute liver failure (ALF) and during orthotopic liver transplantation (OLT). Crit Care 3, P223 (2000). https://doi.org/10.1186/cc596

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Keywords

  • Public Health
  • Blood Sample
  • Liver Transplantation
  • Emergency Medicine
  • Liver Failure