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  • Poster presentation
  • Open Access

The epidural influence on gastric tonometry indicators in pigs submitted to intestinal manipulation

  • 1,
  • 1,
  • 1,
  • 1 and
  • 1
Critical Care200711 (Suppl 3) :P105

  • Published:


  • Catheter
  • Fentanyl
  • Saline Solution
  • Significant Alteration
  • Laboratory Parameter

Background and objectives

The intestinal hypoperfusion occurring during surgeries decreases the gastric pH (pHi), induces acidosis and increases mortality [1]. The epidural improves gastric mucosal perfusion, increases the pHi and stimulates intestinal motility [2]. The present study was undertaken to investigate epidural effects on tonometric indicators in pigs submitted to exploratory laparotomy and to compare the effects of analgesic and anesthetic solutions.


Twenty-seven pigs (weight: 26 ± 2.33 kg) were anesthetized and monitored. The epidural catheter positioning was confirmed by radioscopy (T10–T11). The animals were randomized into a control group (saline solution), a 0.5 group (levobupivicaine S75-R25 0.5%, n = 9), and a 0.05 group (levobupivicaine S75-R25 0.05% + 4 μg/ml fentanyl, n = 9). Fifteen minutes after epidural injection, the animals were submitted to exploratory laparotomy and intestinal manipulation during 45 minutes. The tonometric, hemodynamic and laboratory parameters were collected before the epidural injection (T0), and 60 and 120 minutes after the injection (T1 and T2).


The 0.5 group demonstrated a tendency to improve tonometric indicators: increased the pHi and decreased the gap CO2, but reached no statistically significance. The IRVS decreased in T1 in the 0.5 and 0.05 groups (P < 0.05), remaining reduced at T2 in the 0.5 group (P < 0.05).


The epidural with levobupivicaine 0.5 or 0.05 in pigs submitted to intestinal manipulation had no statistically significant alterations in the tonometric indicators compared with the control group. The pHi and gap CO2 had a tendency to a better performance in the 0.5 group associated with better hemodynamic parameters.

Authors’ Affiliations

Instituto de Ensino e Pesquisa, Hospital Sírio Libanês, São Paulo – SP, Brazil


  1. Sielenkamper AW, Eicker K, Van Aken H: Thoracic epidural anesthesia increases mucosal perfusion in ileum of rats. Anesthesiology. 2000, 93: 844-851. 10.1097/00000542-200009000-00036.View ArticlePubMedGoogle Scholar
  2. Adolphs J, Schmidt DK, Mousa SA, et al: Thoracic epidural anesthesia attenuates hemorrhage-induced impairment of intestinal perfusion in rats. Anesthesiology. 2003, 99: 685-692. 10.1097/00000542-200309000-00025.View ArticlePubMedGoogle Scholar


© BioMed Central Ltd 2007