Volume 11 Supplement 2

27th International Symposium on Intensive Care and Emergency Medicine

Open Access

Influence of ABO blood group polymorphism on mortality in intensive care unit patients

  • M Seubert1
Critical Care200711(Suppl 2):P446

https://doi.org/10.1186/cc5606

Published: 22 March 2007

Introduction

Blood groups may be related to differences in inflammatory responses [1]. We looked at blood group as a risk factor for ICU mortality in general and for patients with sepsis.

Methods

Data were retrospectively collected from all 11,553 patients that were admitted from 1997 to 2005 to our medical/surgical ICU.

Results

ICU mortality and SAPS II score for different blood groups are shown in Table 1. P values are given for the difference between blood groups A and O. No differences were found for age, gender, and reason for admission. No influence of rhesus blood group type was seen on mortality.
Table 1

(abstract P446)

ABO blood group

A

B

AB

O

P value

All patients

n = 4,787

n = 1,168

n = 479

n = 5,119

 

   ICU death (%)

9.5

10.2

10.9

11.2

<0.01

   SAPS II

32 ± 16

33 ± 17

34 ± 18

33 ± 17

NS

Severe sepsis

n = 265

n = 73

n = 34

n = 318

 

   ICU death (%)

24.9

28.8

26.5

32.4

0.05

   SAPS II

49 ± 18

49 ± 18

54 ± 19

51 ± 18

NS

Conclusion

Blood group O is associated with a higher ICU mortality rate than blood group A. The relative risk increase for ICU mortality was 18% for all patients and 30% for patients with severe sepsis.

Authors’ Affiliations

(1)
Academic Medical Center

References

  1. Garratty G: Transfusion Med Rev. 2000, 14: 291. 10.1053/tmrv.2000.16228View ArticleGoogle Scholar

Copyright

© BioMed Central Ltd. 2007

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