- Poster presentation
- Open Access
Circulating levels of tumor necrosis factor alpha, brain natriuretic peptide and cardiac Troponin I upon admission and 31-day mortality in patients with acute decompensated chronic heart failure
- Published: 22 March 2007
Keywords
- Primary Endpoint
- Chronic Heart Failure
- Brain Natriuretic Peptide
- Cardiac Troponin
- NYHA Class
Background
Elevated circulating levels of TNFα, brain natriuretic peptide (BNP) and cardiac Troponin I (cTnI) have been connected with adverse prognosis in patients with chronic heart failure (CHF). However, there are scant data about the predictive value of these biomarkers in combination.
Methods
A total of 577 consecutive patients (mean age: 73 ± 9 years), who were hospitalized for acute decompensation of NYHA class III/IV (65.3% of ischemic etiology) low-output (mean LVEF: 22 ± 5) CHF, were studied. Biochemical markers were measured upon admission. The incidence of 31-day death was the prespecified primary endpoint.
Results
abstract
Conclusion
The present results suggest that in patients hospitalized due to acutely decompensated severe low-output CHF, serum levels of TNFα, BNP and cTnI can be used in combination for enhanced early risk stratification.