- Poster presentation
- Open Access
The effect of tighter glucose control on outcome
© BioMed Central Ltd. 2007
- Published: 22 March 2007
- Serum Glucose
- Glucose Measurement
- Arterial Line
- Lower Blood Glucose
Evidence is accumulating that tight glucose control improves outcome in critically ill patients. This study was performed to evaluate the effect of lower blood glucose levels in critically ill patients on outcome.
The unit is a 10-bed closed-format medical–surgical ICU in a general hospital. Starting in 2003 insulin was prescribed to ICU patients using several nurse-driven computerised protocols, each subsequent protocol aiming for lower glucose levels. From February 2004 until May 2005 protocol 1 was used, aiming for glucose between 5.0 and 9.0 mmol/l; from July 2005 until December 2005 protocol 2 was used, aiming for glucose between 4.5 and 7.5 mmol/l. Serum glucose was measured at 6:00 a.m. in all patients from blood derived from arterial lines or venous puncture. The rest of the day blood glucose was measured either using the Glucotouch (protocol 1) or the AccuCheck (protocol 2) devices. To eliminate differences due to these different methods of measurement, only the 6:00 a.m. glucose measurements done by the central laboratory were studied here. Data were derived from ICU and laboratory databases.
Number of patients
Number of morning glucose measurements
Morning glucose (mean/median)
APACHE II score at ICU admission (mean/median)
Age (years, mean/median)
ICU mortality all patients (%)
Hospital mortality all patients (%)
Mean ICU length of stay (days, mean/median)
Mean hospital length of stay (days, mean/median)
A small but significant decrease in serum glucose probably results in a small but statistically nonsignificant decrease in mortality and length of stay.