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Apparent heterogenity in splanchnic vascular response to norepinephrine during sepsis
Critical Care volume 11, Article number: P36 (2007)
Sepsis alters vascular reactivity. We studied the impact of peritonitis and endotoxemia on hepatic and superior mesenteric arterial contractility.
Materials and methods
We studied fecal peritonitis (P, n = 7), endotoxin-infusion (E, n = 8) and control (C, n = 6) for 24 hours after abdominal surgery and eight control pigs without surgery (SPA). Systemic and regional hemodynamics and ex-vivo splanchnic vascular reactivity to norepinephrine (NE; tissue bath) were measured and cumulative dose–response curves to NE were constructed. Tension was expressed in grams.
CO increased (P < 0.05) in P and E. SMA flow (median (range)) decreased in C from 24 (15–30) to 15 (11–21) ml/kg/min (P = 0.022) (Table 1).
The splanchnic vascular response to NE is heterogenous in sepsis, and SMA is most affected. This may modify blood flow distribution if high NE doses are used.
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Gorrasi, J., Krejci, V., Hiltebrand, L. et al. Apparent heterogenity in splanchnic vascular response to norepinephrine during sepsis. Crit Care 11, P36 (2007). https://doi.org/10.1186/cc5196
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