Effects of volume resuscitation on hepatosplanchnic oxygen consumption, liver mitochondrial function and mortality in endotoxemia
© BioMed Central Ltd. 2007
Published: 22 March 2007
Fluid resuscitation is necessary in sepsis, but positive fluid balance may increase the risk of mortality. We tested the hypothesis that a volume resuscitation strategy may modify liver mitochondrial function and outcome.
Twenty-nine anesthetized pigs received for 24 hours either endotoxin or placebo, and either Ringer's lactate 10 ml/kg/hour or 15 ml/kg/hour + 5 ml/hour HES. Systemic and regional hemodynamics were measured. Liver mitochondrial state 3 and state 4 oxygen consumption were determined.
A prolonged high-volume resuscitation approach during endotoxemia may be associated with impaired hepatosplanchnic oxygen consumption, liver mitochondrial dysfunction and high mortality. The impact of aggressive and prolonged volume administration on hepatosplanchnic oxygenation and mitochondrial function in human sepsis should be determined.