- Poster presentation
- Open Access
Correlation of systemic protein S100β levels with postoperative indicators of neurological damage in supratentorial meningioma surgery
© BioMed Central Ltd 2006
- Published: 21 March 2006
- Postoperative Bleeding
- Neurological Injury
- Average Tumor
- Neurological Damage
Elevated plasma levels of S100β, an astrocyte-derived protein, correlate with neurological deterioration after cardiac surgery  and with poor survival following hypoxia  and neurotrauma  but remain unexplored during elective meningioma surgery. We hypothesized that S100β levels correlate with this tumor's preoperative characteristics and with perioperative neurological injury despite its supratentorial location and non-neural origin.
All patients admitted for meningioma surgery (1 January 2004–31 October 2004) underwent prospective perioperative clinical/radiographic (CT, MRI) neurological evaluation. S100β levels were drawn upon admission and at 2, 24 and 48 hours postoperatively and correlated with clinical/radiological characteristics.
Systemic S100β levels perform poorly as a tumor marker for patients with meningioma but provide early prediction of postoperative neurological injury following meningioma surgery.
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