- Poster presentation
- Open Access
Effects of enalaprilat sodium on plasma NTproANP and NTproBNP levels in healthy volunteers
© BioMed Central Ltd 2006
- Published: 21 March 2006
- Natriuretic Peptide
- Arterial Blood Pressure
- Induction Period
The N-terminal prohormones of the A-type and B-type natriuretic peptides (NTproANP and NTproBNP) are increasingly used as humoral markers for myocardial dysfunction in various clinical settings . No data are available on the effects of angiotensin-converting-enzyme inhibition (ACE-I) on the plasma levels of these hormones.
Ten healthy males were cross-over and double-blind treated with 20 mg enalaprilat sodium or placebo (t0) following 7 days on a sodium enriched-diet and an induction period of 4 days with increasing doses of enalapril. After 4 hours (t4) 15 ml/kg NaCl 0.9% was infused over 60 min. Hemodynamics were determined and blood was sampled at t0, t4, t5, t6, t8, and t10 hours. NTproANP and NTproBNP were determined by radio-luminescence and electrochemoluminescence immunoassays, respectively. Data were analyzed as raw data and as relative changes in comparison with baseline levels.
This suggests that ACE-I does not affect baseline and stimulated plasma NTproANP levels but augments the reactivity of the BNP system in sodium-loaded healthy individuals. ACE-I may thus interfere with NTproBNP determinations in sodium-retaining states.