- Poster presentation
- Open Access
Long-term mortality of critically ill patients with acute renal failure requiring renal replacement therapy: a 5-year population-based cohort study
© BioMed Central Ltd 2006
- Published: 21 March 2006
- Acute Renal Failure
- Renal Replacement Therapy
- Civil Registration System
- Main Study Variable
- Danish Civil Registration System
Despite evidence of a notoriously high short-term mortality of critically ill patients with acute renal failure (ARF), requiring renal replacement therapy (RRT), limited data exist on medium-term and long-term mortality of these patients.
To examine 90-day and 5-year mortality of critically ill patients with ARF, requiring RRT, compared with critically ill patients without ARF, requiring RRT.
A population-based cohort study.
Aarhus University Intensive Care Study Cohort enabled us to identify all patients, aged 15 years or more, with first-time admission to three multidisciplinary ICUs within Aarhus University Hospital from 1999 to 2003. We obtained information on the presence of ARF requiring RRT through the study cohort. Complete follow-up on mortality was obtained from the Danish Civil Registration System. We constructed Kaplan-Meier survival curves, based on the date of ICU admission, for the main study variables (RRT: yes/no and age groups: 15–59, 60+ years) and computed contingency tables for 90-day and 5-year mortality. We computed 90-day mortality rate ratios (MRR) and 5-year MRR for patients surviving 90 days, stratified on age group.
ARF requiring RRT in critically ill patients is associated with a substantial increase in medium-term mortality, most markedly among elderly patients. However, among critically ill patients with ARF requiring RRT who survive the first 90 days after ICU admission, the 5-year mortality seems to be only slightly increased.