- Poster presentation
- Open Access
Blood urea nitrogen and endoscopic pattern relationship in patients with gastrointestinal bleeding
- Published: 21 March 2006
Keywords
- Peptic Ulcer
- Gastrointestinal Bleeding
- Blood Urea Nitrogen
- Healing Ulcer
- Active Bleeding
Introduction
Blood urea nitrogen (BUN) increased in active upper gastrointestinal bleeding. The relationship between BUN and endoscopic pattern is not fully investigated.
Patients and methods
From January 2001 to October 2004, 157 (male/female, 123/34; mean age 69.3 years) were admitted to our hospital because of signs of gastrointestinal bleeding (hemathe-mesis and/or melaena). At admission to the Emergency Department, haemodynamics parameters (cardiac rate, arterial pressure) and laboratory blood tests (complete blood count, creatinine, electrolyte, BUN, albumin) were measured. All patients underwent endoscopy within 8 hours and Forrest's criteria for gastrointestinal bleeding were used: F1, active bleeding; F2, signs of recent bleeding (clot); F3, healing ulcer. During hospitalization, the history, past treatment, haemotransfusion, rebleeding and surgical treatment were also recorded. Data were analyzed in a statistical manner and t tests for unpaired data and univariate analysis were performed.
Results
(abstract P224)
Forrest 1 (23 patients) | Forrest 2 (61 patients) | Forrest 3 (44 patients) | |
---|---|---|---|
Hct (%) | 26.9 ± 7.2 | 28.7 ± 7.3 | 28.2 ± 7.0 |
WBC (mmc) | 11,217 ± 4884 | 11,944 ± 4573 | 10,381 ± 4749 |
PLT (mmc) | 243,147 ± 79,587 | 252,923 ± 84,948 | 225,590 ± 86,796* |
Creatinine (mg/dl) | 1.6 ± 1.0* | 1.1 ± 0.4 | 1.2 ± 0.5 |
BUN (mg/dl) | 53.1 ± 16.6* | 45 ± 15.3 | 40 ± 10.9 |
BUN/creatinine | 39.9 ± 14.1* | 39.4 ± 14.2* | 34.6 ± 11.2 |
Na (mEq/l) | 139.8 ± 5.7 | 138.7 ± 3.5 | 139.7 ± 4.1 |
DBP | 72.6 ± 14.8 | 70.1 ± 13.0 | 75.8 ± 12.9 |
SBP | 125.4 ± 31.1 | 117.7 ± 21.1* | 133.0 ± 25.5 |
Heart rate (bpm) | 93.9 ± 20.8 | 95.1 ± 19.1 | 90.0 ± 13.7 |
Number of blood transfusions | 3.8 ± 2.9* | 3.2 ± 2.7 | 2.1 ± 1.9 |
Hospital stay (days) | 12.0 ± 6.7* | 7.1 ± 4.8 | 8.6 ± 8.1 |
Conclusion
BUN levels and the BUN/creatinine ratio correlate with Forrest's different ulcer patterns. These could identify patients who need an early endoscopic evaluation and more intensive treatment.