- Poster presentation
- Open Access
Prognostic value of pro-atrial natriuretic peptide, pro-adrenomedullin, and pro-endothelin-1 in critically ill patients
© BioMed Central Ltd 2006
- Published: 21 March 2006
- Bypass Surgery
- Systemic Inflammation
- Systemic Inflammatory Response Syndrome
- Coronary Bypass
- Active Mediator
Systemic inflammation is accompanied by cardiovascular dysfunction. Prohormones of cardiovascular active mediators may therefore add important information to the clinical status of these patients. The goal of this study was to describe the prognostic value of three different prohormones in an ICU setting.
Citrate plasma samples of 185 patients with either severe sepsis/septic shock (n = 120) or systemic inflammatory response syndrome (SIRS; n = 65) after coronary bypass surgery have been obtained on admission to the ICU. Midregional pro-atrial natriuretic peptide (MR-proANP), midregional pro-adrenomedullin (MR-proADM), and C-terminal pro-endothelin-1 (CT-proET-1) have been measured by an immunoassay (BRAHMS AG, Germany). The prognostic value for ICU survival was estimated by the area under the curve (AUC) of the receiver–operating characteristics (ROC).
Elevation of all three parameters is significantly associated with a poor prognosis in critically ill patients. Outcome prediction is similar to the APACHE II score.