Volume 10 Supplement 1
Ethyl pyruvate prevents acute lung injury in an experimental multitrauma model
© BioMed Central Ltd 2006
Published: 21 March 2006
Ethyl pyruvate (EP) is a pyruvate derivative that has been reported to improve survival, to decrease proinflammatory cytokine expression (including high mobility group box-1) and to ameliorate organ dysfunction in animals who have lethal sepsis or were subjected to hemorrhagic shock. We examined the potential protective effects of EP administered after multi-trauma on lung oxidative damage and apoptosis in a rat model with delayed resuscitation.
Materials and methods
Discussion and conclusion
These results suggest that a single dose of EP inhibits leukocyte infiltration and oxidative lung damage, even when given 6 hours after the multi-trauma. EP warrants further evaluation as a therapeutic agent to ameliorate multi-traumainduced acute lung injury.
- Foda MA, Marmarou A: A new model of diffuse brain injury in rats. Part II: morphological characterization. J Neurosurg 1994, 80: 301-313. 10.3171/jns.1994.80.2.0301View ArticlePubMedGoogle Scholar
- Bonnarens F, Einhorn TA: Production of a standard closed fracture in laboratory animal bone. J Orthop Res 1984, 2: 97-101. 10.1002/jor.1100020115View ArticlePubMedGoogle Scholar