Ethyl pyruvate prevents acute lung injury in an experimental multitrauma model
© BioMed Central Ltd 2006
Published: 21 March 2006
Ethyl pyruvate (EP) is a pyruvate derivative that has been reported to improve survival, to decrease proinflammatory cytokine expression (including high mobility group box-1) and to ameliorate organ dysfunction in animals who have lethal sepsis or were subjected to hemorrhagic shock. We examined the potential protective effects of EP administered after multi-trauma on lung oxidative damage and apoptosis in a rat model with delayed resuscitation.
Materials and methods
Discussion and conclusion
These results suggest that a single dose of EP inhibits leukocyte infiltration and oxidative lung damage, even when given 6 hours after the multi-trauma. EP warrants further evaluation as a therapeutic agent to ameliorate multi-traumainduced acute lung injury.
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