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Assessment of intravascular retention of hydroxyethyl starch in mild hemorrhagic shock
Critical Care volume 10, Article number: P172 (2006)
Experiments were performed using a mild hemorrhagic (10% of total blood volume) shock model in rats. The blood vessels (A2 and V2) of the cremaster muscle were observed. One hour after hemorrhage was induced, FITC-labeled L-HES (MW 150,000–200,000) or M-HES (MW 175,000–225,000) or H-HES (MW 550,000–850,000) was administered within 15 min. The retention of HES was evaluated by the contrasting density of the brightness of fluorescence on the image stored on the PC.
A retention ratio of HES inside the blood vessel was different among groups. M-HES and H-HES retained in the vessels longer than L-HES, with no difference between M-HES and H-HES (Fig. 1).
M-HES (MW 175,000–225,000) seems to have large molecules, which is enough to maintain the blood volume after hemorrhage.
Komori M, Takada K, et al.: Effects of colloid resuscitation on peripheral microcirculation, hemodynamics, and colloidal osmotic pressure during acute severe hemorrhage in rabbits. Shock 2005, 23: 377-382. 10.1097/01.shk.0000159555.87662.93
Cabrales P, Intaglietta M, et al.: Increase plasma viscosity sustains microcirculation after resuscitation from hemorrhagic shock and continuous bleeding. Shock 2005, 23: 549-555.
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Hitosugi, T., Shimizu, T., Suzuki, S. et al. Assessment of intravascular retention of hydroxyethyl starch in mild hemorrhagic shock. Crit Care 10, P172 (2006). https://doi.org/10.1186/cc4519
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