Supplemental systemic oxygen support with peritoneal oxygenation using a continuous low-pressure oxygen flow system (PEROX)
© BioMed Central Ltd 2006
Published: 21 March 2006
In a continuous peritoneal oxygen flow model, we studied its influence on hemodynamic stability, arterial and mixed venous gases, comparing its effects in normal and in oleic-acid-induced ARDS lungs.
Four pigs were anesthetized, mechanically ventilated and invasively monitored with a Swan-Ganz and femoral catheter. A continuous infusion of dobutamine (2 μ g/kg/hour) was maintained. Arterial pressure, cardiac output, pulmonary compliance, PCWP, and arterial and mixed venous gases were measured every hour. Baseline measures were taken and three laparoscopic trochars were introduced in the abdomen. A continuous oxygen flow of 5–6 l/min was maintained for 8 hours with a sustained intra-abdominal pressure of 5–6 mmHg using a continuous low-pressure flow system (PEROX). At the fifth hour an oleic acid (OA) dose (0.2 mg/kg) was injected into the pulmonary circulation. Afterwards, lungs were histopathologically studied to evaluate the presence of ARDS. A two-way ANOVA with replication was used for the sequential analysis of data.
This experimental model demonstrated that peritoneal oxygenation could be an effective gas interchange-supporting alternative in ARDS. The mechanism of action could be an increase of the mixed venous oxygenation.