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Critical Care

Open Access

Validation of a semi-quantitative bedside procalcitonin measurement in intensive care patients

  • M Vaisman1,
  • A Parodi2,
  • FLB Gutierrez1,
  • R Arkader3,
  • JLF Costa1,
  • PN Gomes1,
  • JRB Martins1 and
  • RCC Filho1
Critical Care20059(Suppl 2):P64

https://doi.org/10.1186/cc3608

Published: 9 June 2005

Keywords

Blood SampleDisease SeveritySerum ConcentrationCare PatientEmergency Medicine

Introduction and objective

Elevation in the serum concentration of procalcitonin (PCT) has been proposed as a marker of disease severity and is associated with systemic infection [1]. This association has led to the proposed use of PCT as a novel biomarker of bacterial sepsis [24]. We sought to evaluate the PCT measurement with a semi-quantitative bedside method (PCTQ).

Methods

From April to July 2003 we evaluated 48 blood samples from 30 patients (14 males with median age 76.64 ± 13.66 years and 16 females with median age 82.06 ± 10.5 years) with sepsis or SIRS in the ICU. PCT levels were measured and grouped into four intervals (<0.5 ng/ml, 0.5–2 ng/ml, 2.0–10 ng/ml and >10 ng/ml) by a quick bedside semi-quantitative method (BRAHMS PCTQ), and the results compared with measurements performed by a quantitative luminometry method (PCTL) (BRAHMS LUMITEST PCT, Germany).

Results

The Kruskall-Wallis ANOVA analysis found a positive and reasonable correlation between the PCTQ and the PCTL for PCT levels >10 ng/ml. There was no significant difference between the other three intervals (<0.5 ng/ml, 0.5–2 ng/ml and 2.0–10 ng/ml) measured by the PCTQ.

Conclusion

This preliminary analysis suggested that the PCTQ can be used to accurately measure PCT levels above 10 ng/ml. Other studies with more samples are necessary to provide more information about levels below 10 ng/ml.

Authors’ Affiliations

(1)
Pró-Cardíaco Hospital, Rio de Janeiro, Brazil
(2)
Laboratório Lâmina Medicina Diagnóstica, Rio de Janeiro, Brazil
(3)
Clínical Hospital, São Paulo University, Brazil

References

  1. Gabay C, Kushner I: Acute-phase proteins and other systemic responses to inflammation. N Eng J Med 1999, 340: 448-454. 10.1056/NEJM199902113400607View ArticleGoogle Scholar
  2. Whang KT, Vath SD, Becker KL, Snider RH, Nylen ES, Muller B, et al.: Procalcitonin and proinflammatory cytokine in interactions in sepsis. Shock 1999, 12: 268-273.View ArticlePubMedGoogle Scholar
  3. Guven H, Alintop L, Baydin A, et al.: Diagnostic value of procalcitonin levels as an early indicator of sepsis. Am J Emerg Med 2002, 20: 202-206. 10.1053/ajem.2002.33005View ArticlePubMedGoogle Scholar
  4. Assicot M, Gendrel D, Carsin H, et al.: High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 1993, 341: 515-518. 10.1016/0140-6736(93)90277-NView ArticlePubMedGoogle Scholar

Copyright

© BioMed Central Ltd 2005

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