Intestinal blood flow and pCO2 gradients in arterial and venous mesenteric blood flow obstruction
© BioMed Central Ltd 2005
Published: 9 June 2005
In this study, we evaluated the systemic and regional pCO2 gradients changes induced by arterial and venous mesenteric blood flow obstruction. In addition, we sought to obtain evidence that systemic markers of splanchnic hypoperfusion can detect the initial changes after intestinal ischemia induced by arterial or venous blood flow interruption.
Fourteen dogs were subjected to 45 min of superior mesenteric artery (SMA-O, n = 7) or vein occlusion (SMV-O, n = 7). Systemic hemodynamic was evaluated through a Swan–Ganz catheter and arterial catheters, while gastrointestinal tract perfusion was evaluated by superior mesenteric vein and serosal blood flows (SMVBF and SBF, ultrasonic flowprobe). Intestinal O2-derived variables, mesenteric–arterial and tonometric–arterial pCO2 gradients (Dmv-apCO2 and Dt-apCO2) were calculated.
Temporary mesenteric congestion was associated with significant hemodynamic and metabolic disturbances. The Dt-apCO2 changes can be detected by systemic markers of splanchnic hypoperfusion after temporary SMV occlusion.