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Open Access

Intestinal blood flow and pCO2 gradients in arterial and venous mesenteric blood flow obstruction

  • RJ CruzJr1,
  • C Correia1,
  • CMF Ribeiro1,
  • T Harada1,
  • LF Poli de Figueiredo1 and
  • M Rocha e Silva1
Critical Care20059(Suppl 2):P38

https://doi.org/10.1186/cc3582

Published: 9 June 2005

Keywords

Superior Mesenteric ArterySystemic MarkerSuperior Mesenteric VeinIntestinal IschemiaInjury Score

Introduction

In this study, we evaluated the systemic and regional pCO2 gradients changes induced by arterial and venous mesenteric blood flow obstruction. In addition, we sought to obtain evidence that systemic markers of splanchnic hypoperfusion can detect the initial changes after intestinal ischemia induced by arterial or venous blood flow interruption.

Methods

Fourteen dogs were subjected to 45 min of superior mesenteric artery (SMA-O, n = 7) or vein occlusion (SMV-O, n = 7). Systemic hemodynamic was evaluated through a Swan–Ganz catheter and arterial catheters, while gastrointestinal tract perfusion was evaluated by superior mesenteric vein and serosal blood flows (SMVBF and SBF, ultrasonic flowprobe). Intestinal O2-derived variables, mesenteric–arterial and tonometric–arterial pCO2 gradients (Dmv-apCO2 and Dt-apCO2) were calculated.

Results

A significant decrease in CO and MAP was detected in the SMV-O group; pCO2 gradients presented a significant increase in both groups (Fig. 1). The histopathologic injury scores were 2.7 ± 0.5 and 4.8 ± 0.2 for the SMA-O and SMV-O groups, respectively.
Figure 1

Figure 1

Conclusion

Temporary mesenteric congestion was associated with significant hemodynamic and metabolic disturbances. The Dt-apCO2 changes can be detected by systemic markers of splanchnic hypoperfusion after temporary SMV occlusion.

Authors’ Affiliations

(1)
Division of Applied Physiology, Heart Institute (InCor)/University of São Paulo, Brazil

Copyright

© BioMed Central Ltd 2005

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