- Poster presentation
- Open Access
Subcutaneous diclofenac at low dose is very effective in treating fever with an accompanying reduction in intracerebral pressure in NICU patients
© BioMed Central Ltd. 2004
- Published: 15 March 2004
- Traumatic Brain Injury
- Mean Arterial Pressure
- Glasgow Coma Scale
- Cerebral Perfusion Pressure
- Scale Motor
Although rigorous control of fever is the current standard of care for the brain-injured patient, patient management strategies currently available are often suboptimal and may be contraindicated.
We investigated a subcutaneous very low dose of diclofenac sodium (DCF SC) to treat fever in the NICU.
DCF SC (0.17 mg/kg [≈ 1/6 fl]) was administered to febrile patients and its effect was recorded continuously for 6 hours on the temperature (T°), intracranial pressure (ICP), cerebral perfusion pressure (CPP), mean arterial pressure (MAP), heart rate (HR) and diuresis. Adverse effects of DCF (allergic, gastrointestinal and central nervous system bleeding) were monitored.
We conclude that DCF SC at low dosage was advantageous and effective. It enabled good reductions in body T° with an associated reduction in the ICP. Side effects on CPP or MAP were minimal, and renal and hepatic functions were not affected.