Skip to main content

Variations of S-100B in early phases of head trauma


S-100 protein is an acidic calcium-binding protein found in astroglia and Schwann cells. Recently, there have been several reports on the relation of the severity of head injury and serum S-100B protein levels in trauma patients, but there are few reports about time course of S-100B protein in the early phase of head injury. In many previous reports, S-100B was reported in units of μg/l. Lately, a new device (YK-150) was developed that can measure serum S-100B protein in pg/ml units.


We showed the course of the concentration of serum S-100B in the acute phase of head injury using the YK-150.

Patients and methods

S-100B serum levels were determined in 10 patients (eight men, two women; mean ± SD, 50.1 ± 20.2 years). There were two cases of severe head injuries (Glasgow Coma Scale [GCS] < 9). Blood samples were taken on admission, 24 and 48 hours after the traumas. Serum S-100B protein concentrations (pg/ml) were measured by ELISA (Yanaihara Industry, Tokyo, Japan).


Initial serum S-100B concentrations were elevated (minimum, 790 pg/ml; maximum, 7,749,669 pg/ml; mean, 979,666 pg/ml). All patients whose serum S-100B concentrations compared with the first-time value decreased at the second point, 24 hours after injury (minimum, 10.1 pg/ml; maximum, 16,990 pg/ml; mean, 5994 pg/ml). After 48 hours, only two patients showed an increase of serum S-100B concentrations and one of these showed the highest level of serum S-100B and died on day 28 (Fig. 1).

figure 1

Figure 1

Discussion and conclusion

Many studies have been done on S-100B that have shown the relation between initial data and poor prognosis. We have also shown patients with slight head injuries who were conscious (GCS > 8) and whose elevated serum S-100B concentrations decreased in the next 24 hours. We suspect it was only the cerebral cell damage that caused the initial increase of serum S-100B concentrations in these head injuries. If there is no secondary brain damage, serum S-100B concentrations will immediately decrease. The YK-150 (Human S-100B ELISA kit) can measure serum S-100B concentrations in 22 ± 4 hours. Using the YK-150, if we can detect a slight variation in early-phase secondary brain damage, we can accurately predict what changes will take place in the patient; and if so, YK-150's efficacy will spread even further.

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Takeda, M., Yuzawa, J., Suzuki, T. et al. Variations of S-100B in early phases of head trauma. Crit Care 8 (Suppl 1), P306 (2004).

Download citation

  • Published:

  • DOI: