Hepatic O2 transport and energy balance in hyperdynamic porcine endotoxin shock: NG-monornethyl-L-arginine (L-NMMA) versus noradrenaline

Table

		Preshock	12 h	18 h	24 h
Liver DO₂	ETX	2.3 [1.9;2.8]	2.2 [1.7;2.7]	2.7 [2.0;3.0]	2.0 [1.4;2.6]
ml/min/kg	NOR^*	2.3 [1.8;2.8]	2.0 [1.5;2.4]	3.1 [2.8;3.6^**	2.6 [1.9;4.1]
	L-NMMA	2.5 [2.2; 2.9]	2.5 [2.1 ;2.61	2.3 [1.7;2.8]	2.0 [1.1;2.6]
Hepatic	ETX	54 ± 5	51 ± 7	51 ± 7	47 ± 10
intracap. HbO₂	NOR	59 ± 6	54 ± 8	61 ± 7	58 ± 12
Mean ± SD	L-NMMA	59 ± 8	56 ± 10	55 ± 10	58 ± 7
Liver VO₂	ETX	0.7 [0.5;1.1]	0.6 [0.4;0.8]	0.6 [0.4;0.8]	0.6 [0.3;0.7]
ml/min/kg	NOR	0.7 [0.5;1.1]	0.6 [0.4;0.8]	0.6 [0.4;0.8]	0.6 [0.3;0.7]
	L-NMMA	0.8 [0.5;0.8]	0.8 [0.5;1.0]	0.6 [0.4;0.8]	0.5 [0.3;0.8]
Hepatic	ETX^*	7.48 [17.46;7.50]	7.38 [7.34;7.42]	7.36 [7.34;7.381	7.30 [7.25;7.34]
venous pH	NOR^*	7.49 [7.46;7.51]	7.33 [7.25;7.34]	7.32 [7.2817.371	7.22 [7.17;7.37]
	L-NMMA^*	7.48 [7.44,7.49]	7.32 [7.31 ;7.341	7.29 [7.26;7.321	7.24 [7.16;7.30]
Hepatic	ETX^*	24 [15;32]	26 [18;30]	34 [28;51]	61 [31;123]
venous Lac/Pyr	NOR^*	31 [21;37]	38 [25;66]	95 [49;1 01]	104 [41 ;204]
ratio	L-NMMA^*	21 [18;29]	28 [28;50]	60 [40;95]	148 [67;187]

ISSN: 1364-8535