- Meeting abstract
Hepatic O2 transport and energy balance in hyperdynamic porcine endotoxin shock: NG-monornethyl-L-arginine (L-NMMA) versus noradrenaline
Critical Care volume 2, Article number: P140 (1998)
Nitric oxide synthase (NOS) inhibition is currently investigated as a treatment of arterial hypotension associated with septic shock, but controversial data are available with respect to hepatic O2 balance. Therefore we studied the effect of NOS inhibition with L-NMMA on liver O2 transport as well as energy balance, in comparison to a standard treatment with noradrenaline (NOR) in a hyperdynamic endotoxin (ETX) shock model.
Thirty anesthetized pigs were randomly assigned to 3 groups 12 h after induction of endotoxic shock with continuous LPS infusion: ETX group: no drug therapy (n = 8); NOR group (n = 11) and L-NMMA group (n = 11): vasopressor therapy with NOR and L-NMMA was titrated to maintain MAP at preshock levels. Hepatic blood flow (Transonic® Doppler ultrasound), O2 kinetics as well as mean and frequency distribution of intracapillary HbO2 saturation (remission spectrophotometry, EMPHO) were measured.
Data are median and interquartile range. *P < 0.05 vs preshock (RM ANOVA on ranks). **P < 0.05 between groups (ANOVA).
Although, in contrast to NOR, L-NMMA did notfurther increase macrocirculatory liver O2 availability, there was no difference between the two treatments with regard to microcircula-tory O2 supply and O2 uptake. Hence, neither of the two treatments improved liver energy balance.
L-NMMA (546C88) was kindly provided by GlaxoWellcome, UK.
About this article
Cite this article
Rieger, K., Träger, K., Vlatten, A. et al. Hepatic O2 transport and energy balance in hyperdynamic porcine endotoxin shock: NG-monornethyl-L-arginine (L-NMMA) versus noradrenaline. Crit Care 2 (Suppl 1), P140 (1998). https://doi.org/10.1186/cc269
- Septic Shock
- Energy Balance
- Hepatic Blood Flow
- Endotoxic Shock