- Poster presentation
- Open Access
The correlation between creatine kinase and myoglobin in critical ill patients with rhabdomyolysis
© BioMed Central Ltd. 2004
- Published: 15 March 2004
- Public Health
- Clinical Practice
- Renal Failure
- Emergency Medicine
Following rhabdomyolysis there is a risk of acute renal failure (ARF). The nephrotoxic molecule is myoglobin (M). In clinical practice, creatine kinase (CK) is, however, measured to estimate the risk of ARF. It is often stated that the elimination of M is unpredictable . The aim of the present study was therefore to investigate the correlation between CK and the effector molecule M.
From 1 January 2003 until 30 June 2003 we prospectively measured CK and M in all patients in the ICU suspected of rhabdomyolysis. To investigate the observed trends further, we retrospectively studied all patients submitted to our ICU within the last 4.5 years with a plasma M > 5000 μg/l. Forty-two patients were included.
In the majority of patients with rhabdomyolysis, M and CK increase and decrease in parallel. Medium-sized molecules such as M are transported directly from the muscle to the blood, while large molecules such as CK are transported with the lymphatic system. Therefore an isolated increase in plasma CK might be observed following mobilisation. An isolated increase in plasma M ought to raise suspicion of abdominal complications.
In patients with rhabdomyolysis, measurement of the nephrotoxic molecule M can be used to predict the risk of ARF.