- Poster presentation
- Open Access
Disturbed alveolar fibrin turnover during pneumonia is associated with reduced activated protein C levels in lungs
© BioMed Central Ltd. 2004
- Published: 15 March 2004
- Bronchoalveolar Lavage
In pneumonia alveolar fibrin turnover is disturbed by activation of coagulation and inhibition of fibrinolysis. The role of natural coagulation inhibitors, such as activated protein C (APC), in lung inflammation is unknown.
In nine patients with unilateral pneumonia (four community-acquired [CAP], five ventilator associated [VAP]) bronchoalveolar lavage fluid (BALF) was obtained from both the infected and the contralateral noninfected lung. BALF levels of coagulation (thrombin–antithrombin complex [TATc]), fibrinolysis (plasminogen activator activity [PAA]), and levels of APC were determined. Ten healthy subjects and 10 mechanically ventilated patients without pneumonia served as controls.
The Wilcoxon signed-ranked test was used for paired samples from the same patients; the Mann–Whitney U test was used for comparisons with controls.
Pneumonia is characterized by a strong procoagulant shift at the site of infection, caused by local activation of coagulation, inhibition of fibrinolysis, and low levels of APC.