- Poster presentation
- Open Access
Sublingual microcirculatory response to fluid challenge in septic shock patients
© BioMed Central Ltd. 2004
- Published: 15 March 2004
- Cardiac Output
- Septic Shock
- Spectral Imaging
- Blood Velocity
During microcirculatory failure in septic shock, the relationship between modifications in macro-circulation and micro-circulation may depend on the resuscitation. How is the microcirculation modified during cardiac output (CO) increase by fluid?
Four septic shock patients (73 ± 12 years old) were investigated with orthogonal polarization spectral imaging (OPS) and with a Swan–Ganz catheter. The SAPS score was 60 ± 8, and norepinephrine was 0.6 ± 0.3 μg/kg/min. In three sublingual areas per patient, the number of vessels (small, medium, large) were quoted as no flow = 0, sludge = 1, moderate = 2, normal = 3, allowing one to compute a microcirculatory ratio for each vessel category. Systemic hemodynamic and OPS data were taken before and within 30 min after fluid bolus (5–7 ml/kg). OPS data presented as median (interquartile range), demographic and hemodynamic data presented as median ± SE.
All sizes of microvessels changed with fluid loading, with different patterns between small and larger vessels, going from recruitment to increased blood velocity.