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  • Open Access

Computerised tomography (CT) in severe acute respiratory syndrome (SARS): late-stage acute respiratory disease syndrome (ARDS) and follow-up findings

  • 1,
  • 2,
  • 2,
  • 2,
  • 2 and
  • 2
Critical Care20048 (Suppl 1) :P37

  • Published:


  • Pneumothorax
  • Lean Body Mass
  • Severe Acute Respiratory Syndrome
  • Computerise Tomography
  • Ground Glass Opacification


SARS is caused by a newly described coronavirus [1]. About 20% of SARS patients require oxygen supplementation and mechanical ventilation in an ICU for respiratory failure and ARDS [2]. We aim to describe the CT findings of patients in the late stage of ARDS caused by SARS, and report changes on long-term follow-up.


A retrospective review of CT findings in eight patients who met CDC criteria for SARS. All patients met criteria for ARDS [3]. CT was performed in late-stage ARDS (more than 2 weeks after onset of ARDS) [4], and after discharge from hospital in survivors. Relevant respiratory and ventilatory parameters, total steroid dose and outcome were recorded.


All mechanically ventilated patients received low pressure (peak pressure < 30–35 mmHg), low volume (tidal volume < 8 ml/kg estimated lean body mass) ventilation [5]. Five patients received prolonged mechanical ventilation (over 14 days), one was only ventilated for 72 hours, and two patients were not ventilated at all. All patients received high-dose pulse methylprednisolone (2.5–7 g total dose). Three patients died and five survived to hospital discharge.

ARDS chronic stage CT findings

Consolidation was present in five patients. Ground glass opacification and interstitial thickening were present in all patients. Three had evidence of fibrosis. Small pulmonary cysts were present in five patients and extrapulmonary gas (pneumothorax) in two. Findings in patients after long-term mechanical ventilation (more than 14 days) and short-term or no ventilation were similar. At follow-up CT (mean 3 months, n = 4), consolidation and extrapulmonary gas had resolved, ground glass opacification improved, but signs of fibrosis had generally progressed.


The CT features of late-stage ARDS caused by SARS are similar to those seen in late-stage ARDS from other causes [4], with no apparent differences between patients who received prolonged mechanical ventilation and those who did not. Fibrotic changes seen in the chronic phase of ARDS do not seem to resolve significantly after discharge.

Authors’ Affiliations

The Chinese University of Hong Kong, Shatin, Hong Kong
Prince of Wales Hospital, Hong Kong


  1. Fouchier RA, Kuiken T, Schutten M, et al.: Aetiology: Koch's postulates fulfilled for SARS virus. Nature 2003, 423: 240. 10.1038/423240aView ArticlePubMedGoogle Scholar
  2. Lee N, Hui D, Wu A, et al.: A major outbreak of severe acute respiratory syndrome in Hong Kong. N Engl J Med 2003, 348: 1986. 10.1056/NEJMoa030685View ArticlePubMedGoogle Scholar
  3. Bernard GR, Artigas A, Brigham KL, et al.: The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994, 149: 818.View ArticlePubMedGoogle Scholar
  4. Gattinoni L, Bombino M, Pelosi P, et al.: Lung structure and function in different stages of severe adult respiratory distress syndrome. JAMA 1994, 271: 1772. 10.1001/jama.271.22.1772View ArticlePubMedGoogle Scholar
  5. Ventilation with lower tidal volume as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome: The Acute Respiratory Syndrome Network N Engl J Med 2000, 342: 1301. 10.1056/NEJM200005043421801Google Scholar


© BioMed Central Ltd. 2004