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Critical Care

Open Access

Transpulmonary thermodilution technique for cardiac output measurements: single versus double indicator

  • MG Costa1,
  • L Pompei1,
  • C Coccia1 and
  • G Della Rocca1
Critical Care20037(Suppl 2):P192

Published: 3 March 2003


CatheterLiver TransplantationJugular VeinBody Surface AreaBolus Injection


The aim of the study was to compare ITBVI and EVLWI measured by the double indicator (ITBVITD, EVLWITD) [1] with those estimated by the single indicator technique (ITBVIST, EVLWIST) [2].


Thirty-five patients (24 male, 11 female), mean age 49 (10) years, body surface area 1.8 (0.2) m2, undergoing liver transplantation (Ltx) were studied. Each patient received a pulmonary artery catheter placed via the right internal jugular vein and a 4 Fr thermistor-tipped fiberoptic catheter for thermal dye dilution inserted into the descending aorta connected to the COLD-Z021 (Pulsion Medical System, Munich, Germany). For the double indicator method, a bolus injection was made with cooled (0–4°C) indocyanine green dissolved in glucose 5% in a concentration of 2 mg/ml, and for the single indicator technique 15 ml cooled normal saline was used. Bland and Altman analysis was used for statistical evaluation.


The mean bias between ITBVITD and ITBVIST was 8.6 ml/m2 with a standard deviation of 61.8 ml/m2, and the mean bias between EVLWITD and EVLWIST was -0.2 ml/kg with a standard deviation of 2.2 ml/kg.


The single transpulmonary thermodilution technique is as accurate as the double indicator method for ITBVI and EVLWI estimation.

Figure 1

Figure 2

Authors’ Affiliations

Clinica di Anestesia, University of Udine, Udine, Italy


  1. Sakka SG, et al.: J Crit Care 1999, 14: 78-83. 10.1016/S0883-9441(99)90018-7View ArticlePubMedGoogle Scholar
  2. Sakka SG, et al.: Intensive Care Med 2000, 26: 180-187. 10.1007/s001340050043View ArticlePubMedGoogle Scholar


© BioMed Central Ltd 2003