The effect of vasopressin on gastric perfusion in catecholamine-dependent septic shock patients
© BioMed Central Ltd 2003
Published: 3 March 2003
To study the effect of continuous infusion of vasopressin on the splanchnic circulation in septic shock patients.
Prospective clinical study.
Intensive care unit in a teaching hospital.
Eleven consecutive patients with documented septic shock who remained hypotensive despite norepinephrine infusion at a rate of ≥ 0.2 μg/kg per min.
Insertion of a gastric tonometry catheter; continuous infusion of vasopressin 0.04 U/min during 4 hours.
Measurements and main results
P(g–a)CO2 gap, blood pressure and cardiac index were recorded at baseline and after 15, 30, 60, 120 and 240 min.
In norepinephrine-dependent septic shock patients, continuous infusion of low-dose vasopressin results in a significant and dose-dependent increase of the P(g–a)CO2 gap compatible with gastrointestinal hypoperfusion.
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