- Meeting abstract
The effect of vasopressin on gastric perfusion in catecholamine-dependent septic shock patients
Critical Care volume 7, Article number: P047 (2003)
To study the effect of continuous infusion of vasopressin on the splanchnic circulation in septic shock patients.
Prospective clinical study.
Intensive care unit in a teaching hospital.
Eleven consecutive patients with documented septic shock who remained hypotensive despite norepinephrine infusion at a rate of ≥ 0.2 μg/kg per min.
Insertion of a gastric tonometry catheter; continuous infusion of vasopressin 0.04 U/min during 4 hours.
Measurements and main results
P(g–a)CO2 gap, blood pressure and cardiac index were recorded at baseline and after 15, 30, 60, 120 and 240 min.
The median P(g–a)CO2 gap increased from 5 mmHg at baseline to 19 mmHg after 4 hours (P = 0.022; Fig. 1). Blood pressure (mean ± SD) increased from 61 ± 13 mmHg at baseline to 68 ± 9 mmHg after 4 hours (P = 0.055). No significant changes in cardiac index were noted (P = 0.978). There was a strong correlation between median plasma levels of vasopressin and the median P(g–a)CO2 gap (r2 = 0.98) as is shown in Fig. 2.
In norepinephrine-dependent septic shock patients, continuous infusion of low-dose vasopressin results in a significant and dose-dependent increase of the P(g–a)CO2 gap compatible with gastrointestinal hypoperfusion.
Patel BM, Chittock DR, Russell JA, Walley KR: Beneficial effects of short-term vasopressin infusion during severe septic shock. Anesthesiology 2002, 96: 576-582. 10.1097/00000542-200203000-00011
Holmes CL, Walley KR, Chittock DR, Lehman T, Russell JA: The effects of vasopressin on hemodynamics and renal function in severe septic shock: a case series. Intensive Care Med 2001, 27: 1416-1421. 10.1007/s001340101014
Tsuneyoshi I, Yamada H, Kakihana Y, Nakamura M, Nakano Y, Boyle WA III: Hemodynamic and metabolic effects of low-dose vasopressin infusions in vasodilatory septic shock. Crit Care Med 2001, 29: 487-493. 10.1097/00003246-200103000-00004
About this article
Cite this article
van Haren, F., Rozendaal, F. & van der Hoeven, J. The effect of vasopressin on gastric perfusion in catecholamine-dependent septic shock patients. Crit Care 7, P047 (2003). https://doi.org/10.1186/cc1936
- Septic Shock
- Continuous Infusion