Relationship between platelet counts, C-reactive protein and plasma fibrinolytic capacity in critically ill patients
© BioMed Central Ltd 2003
Published: 3 March 2003
Multiple Organ Failure (MOF) complicating the sepsis remains the first cause of death in the ICU. A recent study showed that vascular endothelial damage was the primary cause of MOF in patients with thrombopenia and that humoral mediators played a major role in the development of this process . Other parameters like C-protein reactive were also probably important via a direct effect on endothelial cells and increasing the secretion of IL-6. In this study, we aimed to evaluate the relation between the platelet counts (PC), the C-reactive protein and plasma fibrinolytic capacity (as a marker of endothelium dysfunction) in ICU patients.
We studied blood samples of ICU patients with (n = 11) and without (n = 21) sepsis at the first day of admission. Fibrinolytic capacity was evaluated by the Euglobulin Clot Lysis Time (ECLT) determined by a new method . We also collected biological data and the SAPS II score for each patients. The correlations were depicted by Spearman's test.
The ECLT was significantly correlated with CRP (R = 0.64; P < 0.001) and PC (R = -0.4; P = 0.02). The two-way ANOVA showed that the sepsis status increased significantly the ECLT (P = 0.023) and that platelets under 208,500 cells/μl (median of the histogram of PC was used as the cut-off) also increased the ECLT (P = 0.023). However, there was no interaction (P = 0.184).
Sepsis (n = 11)
Nonsepsis (n = 21)
WBC (× 103 cells/μl)
Platelets (× 103 cells/μl)
- Hirokazu U, et al.: Crit Care Med 2002, 30: 2242-2248.View ArticleGoogle Scholar
- Zouaoui Boudjeltia K, et al.: BMC Biotechnology 2002, 2: 8. 10.1186/1472-6750-2-8View ArticlePubMedGoogle Scholar
- Vincent JL, et al.: Crit Care Med 2002, 30: S313-S317. 10.1097/00003246-200205001-00022View ArticlePubMedGoogle Scholar