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Prognostic value of indocyanine green-plasma disappearance rate in critically ill patients
Critical Care volume 6, Article number: P200 (2002)
Monitoring of regional organ blood flow and function is often crucial for guiding therapy in critically ill patients. In particular, indocyanine green-plasma disappearance rate (ICG-PDR) has been proposed for the assessment of liver function and its value has been demonstrated in evaluation of donor organs  and as prognostic marker in 39 critically ill patients .
We retrospectively analyzed 336 critically ill patients (120 female, 216 male, age 10–89 years, mean 53 ± 19 years) who were treated in our ICU between 1996 and 2000. All these patients were hemodynamically monitored by the transpulmonary double indicator (thermo-dye) dilution technique. Statistical analysis for ICG-PDR in survivors (n = 168) and non-survivors (n = 168) was based on the lowest value of ICG-PDR in each individual.
ICG-PDR was significantly lower in non-survivors than in survivors (median 6.4 vs 16.5 [%/min]) (P < 0.001). Mortality was about 80% in patients with ICG-PDR below 8 (%/min) and survival about 80% in those with ICG-PDR above 16 (%/min). Within three different sub-groups of patients (sepsis, ARDS, and others) survivors had significantly higher ICG-PDR than non-survivors (Fig.).
ICG-PDR correlates well with survival of critically ill patients. For the future, measurement of ICG-PDR seems to be a promising clinical tool, particularly since accurate and non-invasive transcutaneous assessment at the bedside has become possible.
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Sakka, S., Meier-Hellmann, A. & Reinhart, K. Prognostic value of indocyanine green-plasma disappearance rate in critically ill patients. Crit Care 6, P200 (2002). https://doi.org/10.1186/cc1664
- Public Health
- Blood Flow
- Liver Function
- Emergency Medicine
- Prognostic Marker