- Meeting abstract
- Published:
Monitoring of intrathoracic blood volume in early septic patients: its correlation with survival
Critical Care volume 6, Article number: P197 (2002)
Introduction
Early goal directed therapy improves survival in sepsis, trough optimisation of contractility, oxygen balance and correction of fluids deficit [1]. Aim of the study is to investigate whether optimisation of ITBV (intrathoracic blood volume) an index of preload, could be a therapeutic end point in early sepsis, as previously demonstrated in burns patients [2].
Methods
Sixty septic patients (Bone criteria) were monitored with a central vein catheter and an artery femoral catheter connected to a fiberoptic system (Cold Z-02; Pulsion Medizintechnic) Patients were submitted to a fluid management protocol to obtain MAP = 75 mm/Hg, maintaining ITBVI 800-1000 ml/m2 and EVLWI <7.5 ml/kg. At T0 (basal) and after 24 (T1), 48 (T2) 72 (T3) and 96 hours (T4) main volumetric, hemodynamic data were studied. ANOVA test was used to compare changes over time. A Fisher test was used to compare categorical data.
Results
Thirty-two patients survived (Group A) and 28 died at 28 days (Group B). ITBVI was higher in Group A than Group B at T1 and T2 (Fig. 1). And ITBVI > 800 ml/m2 at T1 and T2 was predictive of survival.
Comment
(1) ITBVI improves earlier in survivors then non survivors during a reanimation period. (2) This improvement has a predictive value. (3) Optimisation of ITBVI during early sepsis should be evaluated in further trials.
References
N Engl J Med 2001, 345: 1368-1377. 10.1056/NEJMoa010307
J Trauma 2000, 48: 728-734.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Turani, F., Colella, D., Leonardis, F. et al. Monitoring of intrathoracic blood volume in early septic patients: its correlation with survival. Crit Care 6 (Suppl 1), P197 (2002). https://doi.org/10.1186/cc1659
Published:
DOI: https://doi.org/10.1186/cc1659