Hemostatic and fibrinolysis markers in serum and shed mediastinal blood after elective coronary artery bypass grafting
© Biomed central limited 2001
Published: 1 March 2002
Reduction of homologous blood products in cardiac surgery is mainly achieved by autologous blood salvage. One of the most customary methods consists in autotransfusion of shed mediastinal blood within the first 6 hours after surgery. Aim of this prospective study was to compare serum and shed mediastinal blood qualities of hemostatic and fibrinolysis markers early after elective coronary artery bypass grafting (CABG).
Forty-seven patients (mean age 68.1 ± 6.9, 15 female/ 32 male) underwent first-time elective CABG with extracorporal circulation via median sternotomy. Activated partial thromboplastin time (aPTT), prothrombin time (Quick's value), international normalized ratio (INR), thrombin time, and fibrinogen (factor I) in arterial blood and shed mediastinal blood were measured after admission to the ICU and 6 hours after unclamping the aorta.
After admission to the ICU
6 hours after unclamping the aorta
Quick's value (%)
Thrombin time (s)
Mediastinal shed blood is excessively activated regarding coagulation and fibrinolysis. In patients undergoing transfusion of higher quantities of shed blood might cause postoperative excessive bleeding.