These data confirm our hypothesis about the role of well known markers as IL6 and TNF-a in the inflammatory response associated with severe pre-eclampsia and HELLP syndrome [1]. This is also true for some natural coagulation inhibitors and specially for AT III [2]. Protein C and TFPI show, in these data, a new significant role and contribute to confirm a multiple genesis for the coagulation disorders and the organ dysfunction associated to this obstetric disease. In addition to the well known endothelial dysfunction there is a systemic activation of maternal inflammatory cell responses in association with clotting alterations and this is supported by the correlation between the high levels of the pro-inflammatory cytokines and the low levels of coagulation inhibitors. The inhibitory substitutive treatment with AT III, that we have experienced, and with these natural inhibitors (specially Protein C) could modulate the excessive and altered inflammatory response and might restore a normal coagulation and a good organ function reducing the admission and/or the permanence of these patients in ICU.