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Granulocyte colony-stimulating factor (G-CSF) enhances superoxide production in acute liver failure (ALF): an in vivo effect

Methods

The in vitro ability of G-CSF to improve neutrophil superoxide production has been previously demonstrated in ALF patients [1]. However, the in vivo effect on neutrophil function is unknown. Therefore G-CSF was given to three groups of ALF patients (n = 6) as a daily infusion at four different dosages (25, 50, 100 and 150 µg/m2). Superoxide production was measured after fMLP stimulation, before and at 24 and 96 h.

Results

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G-CSF significantly enhanced superoxide production at 96 h (P < 0.05). Furthermore, this effect was observed at doses below the standard therapeutic dose of 150 µg/m2. Further studies are needed to determine the therapeutic value of G-CSF in the prevention and treatment of infection in ALF patients.

Table

References

  1. 1.

    Rolando N, Clapperton M, et al: Effect of granulocyte colony stimulating factor (G-CSF) on neutrophil function in patients with acute liver failure. J Hepatol. 1996, 25: 100-

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Clapperton, M., Wendon, J. & Rolando, N. Granulocyte colony-stimulating factor (G-CSF) enhances superoxide production in acute liver failure (ALF): an in vivo effect. Crit Care 2, P015 (1998). https://doi.org/10.1186/cc145

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Keywords

  • Public Health
  • Superoxide
  • Emergency Medicine
  • Liver Failure
  • Therapeutic Dose