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Could preoperative and postoperative optimal nutrition support modulate the inflammatory response and clinical outcome of severe malnourished surgical patients with gastrointestinal neoplasia?
Critical Care volume 19, Article number: P396 (2015)
Introduction
Our aim was to assess whether perioperative and postoperative optimal 7-day nutrition support could modulate the inflammatory status and clinical outcome of severe malnourished patients with surgery for gastrointestinal neoplasia.
Methods
A prospective randomized study of 64 patients with gastrointestinal neoplasia, severe malnourished BMI <18.5, albumin level <3 g/dl, BW loss >10%, NRS >3, scheduled for surgery, allocated into two groups. Group A: 32 patients, minimal enteral nutrition in the postoperative period according to tolerance, medium 500 kcal/day. Group B: 32 patients received optimal parenteral nutrition support (25 kcal/kg/day) 3 days before surgery and continued for at least 4 days postoperatively. We measured CRP, fibrinogen, IL-6, TNF, albumin level preoperative and at 96 hours, the incidence of complications, and the length of ICU stay.
Conclusion
Perioperative optimal nutrition support for at least 7 days could modulate the inflammatory status and clinical outcome of severe malnourished surgical neoplasic patients.
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Mirea, L., Pavelescu, D. & Grintescu, I. Could preoperative and postoperative optimal nutrition support modulate the inflammatory response and clinical outcome of severe malnourished surgical patients with gastrointestinal neoplasia?. Crit Care 19 (Suppl 1), P396 (2015). https://doi.org/10.1186/cc14476
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DOI: https://doi.org/10.1186/cc14476