- Poster presentation
- Open Access
Randomized, double-blind, placebo-controlled study of the efficacy of four probiotics to modify the risk for postoperative complications in colorectal surgery
Critical Care volume 19, Article number: P390 (2015)
Heterogeneous published Results led us to conduct a clinical trial to assess the efficacy of a new formulation of four probiotics (P) as prophylaxis for complications after colorectal surgery.
A double-blind, placebo-controlled randomized study was conducted enrolling patients undergoing colorectal cancer surgery. Placebo or a formulation of L. acidophilus, L. plantarum, B. lactis and S. boulardii was administered starting 1 day before operation and continuing for 15 days post operation. Patients were followed-up for 30 days with the development of postoperative complications as the primary outcome. PAXGene tubes and serum were collected on postoperative day 4 for measurement of gene expression and serum cytokines (http://ClinicalTrials.gov NCT02313519).
Administration of P significantly decreased the rate of all postoperative major complications (28.6% vs. 48.8% of placebo, P = 0.010, odds ratio: 0.42). Major benefit was found in the reduction of the postoperative pneumonia rate (2.4% vs. 11.3%, P = 0.029), of wound infections (7.1% vs. 20.0%, P = 0.020), of anastomotic leakage (1.2% vs. 8.8%, P = 0.031) and of the need for mechanical ventilation (20.2% vs. 35.0%, P = 0.037). The time until hospital discharge was shortened as well. Gene expression of SOCS3 was positively related with circulating IL-6 in the P group but not in the placebo group (Figure 1).
The studied P formulation significantly decreased the risk of postoperative complications, namely mechanical ventilation, infections and anastomotic leakage. Modulation of the gene expression of SOCS3 is one suggested mechanism.
About this article
Cite this article
Kotzampassi, K., Stavrou, G., Damoraki, G. et al. Randomized, double-blind, placebo-controlled study of the efficacy of four probiotics to modify the risk for postoperative complications in colorectal surgery. Crit Care 19 (Suppl 1), P390 (2015). https://doi.org/10.1186/cc14470
- Colorectal Cancer
- Mechanical Ventilation
- Postoperative Complication