Volume 5 Supplement 4
Serum N-terminal pro brain natriuretic peptide (NTproBNP) in perioperative cardiac surgical patients
© BioMed Central Ltd 2001
Published: 7 November 2001
Brain natriuretic peptide (BNP) is released from stretched ventricular wall. BNP particularly the N-terminal portion of proBNP (NTproBNP) is a sensitive marker of congestive heart failure and predictor of outcome . Variations in NTproBNP in cardiac surgical patients are not well described . We investigated changes in NTproBNP in relation to clinical progress in open heart surgery patients.
We measured serum concentrations of NTproBNP in 15 perioperative cardiac surgical patients in a pilot observational study using an electrochemiluminescent sandwich immunoassay (Elecsys 2010, Roche Diagnostics: interassay c.v. 5.0% at 380 ng/l, 4.4% at 8700 ng/l, 5.0% at 13000 ng/l, detection limit 20 ng/l, upper measuring limit 25,000 ng/l). We collected samples on induction of anaesthesia, at the end of the surgery, 12 hourly for 3 days, then daily for 3 days.
Changes in serum NTproBNP in cardiac surgical patients may predict clinical course.
- Bettencourt P, Ferreira A, Dias P, Castro A, Martins L, Cerqueira-Gomes M: Evaluation of brain natriuretic peptide in the diagnosis of heart failure. Cardiology 2000, 93: 19-25. 10.1159/000006997View ArticlePubMedGoogle Scholar
- Morimoto K, Mori T, Ishiguro S, Matsuda N, Hara Y, Kuroda H: Perioperative changes in plasma brain natriuretic peptide concentrations in patients undergoing cardiac surgery. Surgery Today 1998, 28: 23-29. 10.1007/s005950050072View ArticlePubMedGoogle Scholar