Serum N-terminal pro brain natriuretic peptide (NTproBNP) in perioperative cardiac surgical patients
© BioMed Central Ltd 2001
Published: 7 November 2001
Brain natriuretic peptide (BNP) is released from stretched ventricular wall. BNP particularly the N-terminal portion of proBNP (NTproBNP) is a sensitive marker of congestive heart failure and predictor of outcome . Variations in NTproBNP in cardiac surgical patients are not well described . We investigated changes in NTproBNP in relation to clinical progress in open heart surgery patients.
We measured serum concentrations of NTproBNP in 15 perioperative cardiac surgical patients in a pilot observational study using an electrochemiluminescent sandwich immunoassay (Elecsys 2010, Roche Diagnostics: interassay c.v. 5.0% at 380 ng/l, 4.4% at 8700 ng/l, 5.0% at 13000 ng/l, detection limit 20 ng/l, upper measuring limit 25,000 ng/l). We collected samples on induction of anaesthesia, at the end of the surgery, 12 hourly for 3 days, then daily for 3 days.
Changes in serum NTproBNP in cardiac surgical patients may predict clinical course.
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